Asymmetric Cell Division: A CAB Driver for Spindle Movements
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چکیده
منابع مشابه
Asymmetric Cell Division: A CAB Driver for Spindle Movements
To divide asymmetrically, a cell must position the mitotic spindle relative to localized cell fate determinants. Recent work in the early ascidian embryo reveals the function of a single factor that coordinates this act to control cleavage pattern and cell fate determination.
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Asymmetric cell division can produce daughter cells with different developmental fates and is often accompanied by a difference in cell size. A number of recent genetic and in vivo imaging studies in Drosophila and Caenorhabditis elegans have begun to elucidate the mechanisms underlying the rearrangements of the cytoskeleton that result in eccentrically positioned cleavage planes. As a result, ...
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Development of a multicellular organism from a fertilized egg depends on a precise balance between symmetric cell divisions to expand the pool of similar cells, and asymmetric cell divisions to create cell-type diversity. Spindle orientation can influence the generation of symmetric or asymmetric cell fates depending on how it is coupled to cell-intrinsic polarity cues, or how it is positioned ...
متن کاملAsymmetric Division: AGS Proteins Position the Spindle
There was a time, not long ago, when finding a role for heterotrimeric G proteins in a biological process was taken as a sign that cells were signaling to other cells. The functions of heterotrimeric G proteins depended on cell–cell signaling: cells sent signals that could activate serpentine receptors on the surfaces of other cells, and the job of heterotrimeric G proteins was to relay these s...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2007.06.040